The aim of this study was to compare cardiac output and plasma propofol concentrations in the supine and prone positions in healthy adult patients presenting for lumbar spine surgery. Patients received propofol and remifentanil via effect-site steered target-controlled infusions. Cardiac output and plasma propofol concentration were compared during 20 minutes in the supine position and 20 minutes after positioning on a Wilson frame. Cardiac output did not change significantly over 20 minutes in either position (P = 0.37) and was similar at 20 minutes in the supine (6.1 [1.6] l/minute) and prone positions (6.1 [1.9] l/minute) (P = 0.87). Propofol concentrations were similar in the supine and prone positions at 20 minutes (2.55 [0.89] and 2.53 [0.90] microg/ml; P = 0.93). We conclude that prone positioning on the Wilson frame does not affect cardiac output or plasma propofol concentration.
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机译：这项研究的目的是比较参加腰椎手术的健康成人患者仰卧位和俯卧位的心输出量和血浆丙泊酚浓度。患者通过作用部位导向靶控输注接受丙泊酚和瑞芬太尼。在仰卧位20分钟内和威尔逊镜架上20分钟后比较心输出量和血浆丙泊酚浓度。两个位置的心输出量在20分钟内均无显着变化（P = 0.37），仰卧位（6.1 [1.6] l / min）和俯卧位（6.1 [1.9] l / min）的心输出量在20分钟时相似（P = 0.87）。 20分钟时仰卧位和俯卧位的异丙酚浓度相似（2.55 [0.89]和2.53 [0.90] microg / ml; P = 0.93）。我们得出的结论是，俯卧在Wilson框架上的位置不会影响心输出量或血浆丙泊酚浓度。
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