Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

摘要

Following from the evaluation of diferent types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as β-lactams.