Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

摘要

The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease cathepsin C is detailed. Optimization of the template with regardto plasma stability led tothe identification ofcompound 17, a potentcathep- sin C inhibitor with excellent selectivity over other cathepsins and potent in vivo activity in a cigarette smoke mouse model.