Dr. Kendler Replies

摘要

To the Editor: I appreciate the comments of Dr. Rietschel et al. on my recent article (1). I suspect that a long face-to-face discussion between us would yield many more areas of agreement than disagreement. For example, I argued that we will not easily move from gene discovery of the modest effect-sized loci that are likely to exist for psychiatric disorders directly to major overhauls of our diagnostic system. However, I agree with Dr. Rietschel et al. that gene discovery could, and hopefully will, lead to clarification of pathophysiology. That in turn might lead to insights that would usefully inform our nosology.