Protective efficacy of a formalin-inactivated vaccine against viral hemorrhagic septicemia (VHS) inoblong rockfish Sebastes oblongus

摘要

We evaluated the protection against viral challenge afforded to oblong rockfish Sebastes oblongus by vaccination with formalin-inactivated VHS virus. The cumulative mortalities in the fish that received the vaccine at 12°C and 20°C were significantly lower than those in the control fish given PBS at the same temperatures (P く 0.01). The relative percentage survival of all the vaccinated fish was 100%. Therefore, immunization with the formalin-inactivated vaccine at both 20°C and 12°C provided significant protection to oblong rockfish against VHS. This is the first report of an efficient vaccine against VHS in the oblong rockfish.