口蹄疫灭活疫苗对不同亚洲I型病毒株的交叉保护效果

摘要

To evaluate the relation of vaccine virus strain of Foot and Mouth Disease virus （FMDV） inactivated vaccine, a batch of FMDV inactivated vac, cine was compounded respectively with Asia-1 KZ / 03 strain and Asia I/JSL strain according to related regulations and immune animals. The results of challenge protection efficiency of the homologous virulent strain showed that Asia-1 KZ / 03 strain was 7.05 PD50 for the FMD Bivalent Inactivated Vaccine（Type O and Asial ,OHM/02 ＋Asia I KZ/03）, and Asial / JSL/GSZY / 06 strain was 7.29 PDso for the FMD Bivalent Inactivated Vaccine （Type O and Asial ,OHM/02 ＋Asia I/ JSL）; the FMD Bivalent Inactivated vaccine （Type O and Asial ,OHM/02 ＋Asia [ KZ/03） resistances to the hierology virulent strain of type Asial （Asial/JSL/GSZY/06 stain） was 7.19 PDso. With that, the vaccine preparation with Asia-I KZ / 03 virus strains against the Asial / JSUGSZY / 06 virus has a good crossprotection effect, can achieve cross homologous strains of the vaccine preparation immunity effect%分别用亚洲1型Asia-1KZ／03毒株和AsiaI／JSL毒株按口蹄疫灭活疫苗相关生产规程配制口蹄疫O型、亚洲I型二价灭活疫苗免疫动物，检测2种毒株的攻毒保护效果。结果显示，用Asia-1KZ／03株病毒配制的口蹄疫O型、亚洲I型二价灭活疫苗用同源病毒株攻击，保护效果可达7．05PD∞／头份，用异源病毒株Asial／JSL／GSZY／06攻击，保护效果可达7．19PD50/头份；用AsiaI，JSL株病毒配制的口蹄疫O型、亚洲I型二价灭活疫苗对江苏毒同源毒株Asial／JSL／GSZY／06攻击，保护效果可达7．29PD50/头份。说明，用Asia-1KZ／03病毒株制备的疫苗对Asial／JSL／GSZY／06病毒具有良好的交叉保护效果，可达到同源病毒株制备疫苗的免疫效果。