strain of foot-and-mouth disease virus type c - 65 - 67, used for the assessment of иммуногенности foot-and-mouth disease vaccine

摘要

strain of the virus type c - 65 - 67, used for the assessment of u0438u043cu043cu0443u043du043eu0433u0435u043du043du043eu0441u0442u0438 foot-and-mouth disease vaccine. stored in the strains of the all union research institute under the u044fu0449u0443u0440u043du043eu0433u043e with 65 / 67. morphological characteristics. structure of a foot-and-mouth disease virus. u0430u043du0442u0438u0433u0435u043du043du0430u044f structure. in the reaction of complement are not the properties of the source of the virus.cross reaction in neutralization of neutralized u0430u043du0442u0438u0441u044bu0432u043eu0440u043eu0442u043au043eu0439 obtained on foot-and-mouth disease virus with 65 / 67.u043fu0430u0442u043eu0433u0435u043du043du043eu0441u0442u044c.u043fu0430u0442u043eu0433u0435u043du0435u043d adult white mice of all weight categories and causes their death; u043fu0430u0442u043eu0433u0435u043du0435u043d for guinea pigs, aphthous ulcer are not formed, is characterized by u043cu0438u043eu0442u0440u043eu043fu043du043eu0441u0442u044cu044e and a loss of 40 - 60% of infected animals; weak u043fu0430u0442u043eu0433u0435u043du0435u043d for cattle.is the education of atypical u0430u0444u0442 only site of the virus in the mucous membrane of the tongue without generalization u044fu0449u0443u0440u043du043eu0433u043e process; titer u0438u043du0444u0435u043au0446u0438u043eu043du043du043eu0441u0442u0438 on mouse x - u0441u043eu0441u0443u043du0430u0445 10u00b11,0 ld / ml in adult mice 10u00b11,0 ld / ml. reproduction in the body of newborn and adult mice.virus 180 185 passages is characterized by a high u0440u0435u043fu0440u043eu0434u0443u043au0446u0438u043eu043du043du043eu0439 activity in newborn and adult mice body and accumulates to 10u00b11,0 and 10u00b11,0 ld / ml the work for me for 18 to 48 h of infection.