Spray chilling of drugs with lipids: Considerations in the development of controlled and enhanced release lipid particles

摘要

Lipid based delivery systems continue to attract considerable interest within the pharmaceutical arena, not only because of their ability to improve bioavailability via their interaction with the components of the gastrointestinal tract [1-5] but also because they may be used to manipulate release rates in vitro and in vivo [6-10]. One of the challenges associated with their use, however, is that their consistency tends to be liquid, semi-solid or, at best, a relatively pliable solid, which does not lend itself well to conventional dosage form preparation techniques. In mitigation, however, they do tend to melt at low temperatures and in a reversible manner without degradation, hence such systems are suitable for techniques whereby liquefaction is an inherent step.