Population pharmacokinetics of ethanamizuril in normal and coccidiosis-infected chickens through ultra-performance liquid chromatography-Tandem Mass Spectrometry

摘要

Ethanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two-compartment model with first-order absorption after oral administration in chickens. Its clearance rate and volumn of central compartment distribution (V-c) were affected by age and body weight, and volumn of central compartment distribution (V-c) and volume of peripheral compartment distribution(V-p) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.