Ginsenoside Rg6 Modulates Platelet Function and Thrombus Formation via Inhibition of Phosphoproteins

摘要

The root of Panax ginseng is used in traditional medicine in Eastern Asia and various studies have reported that P. ginseng has inhibitory effects on cardiovascular disease including stroke and myocardial infarction. Each factor causing cardiovasculardisease is known to have various processes. Among these processes, platelets are the most important. Therefore, inhibiting the activity of platelets is an essential factor for the prevention of platelet-mediated cardiovascular diseases. This study examined the inhibitory mechanism of ginsenoside Rg6 (G-Rg6) on human platelet aggregation and thrombus formation. Collagen-induced human platelet aggregation was inhibited dose-depend-ently by G-Rg6, and it suppressed the collagen-induced elevation of [Ca~(2+)]i mobilization. In addition, G-Rg6 suppressed collagen-induced fibrinogen binding to aIIb/(33 and clot retraction. Thus, G-Rg6 has an inhibitory effect on human platelet activation and thrombus formation, highlighting its potential as a natural substance for preventing thrombosis and cardiovascular diseases.