gamma delta T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

摘要

The aim of the current review is to summarize the results of studies on the role of gamma delta T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of gamma delta T is still not fully understood. It seems that there are two distinct subpopulations - one exacerbating the disease (IL-17-producing) and the other playing a protective role (IFN-gamma-secreting). Nevertheless, future studies are required for an understanding of gamma delta T cells role in multiple sclerosis.