Evaluation of multiple alternative instrument platforms for targeted and non‐targeted dioxin and furan analysis

Stultz Conner; Jobst Karl J.; Haimovici Liad; Jones Rhys; Besevic Sladjana; Byer Jonathan; Organtini Kari L.; Kolic Terry; Reiner Eric J.; Dorman Frank L.

摘要

Abstract >The use of gas chromatography coupled to high‐resolution magnetic sector mass spectrometers (GC‐HRMS) is well established for dioxin and furan analysis. However, the use of gas chromatography coupled to triple quadrupole (MS/MS) and time of flight (TOF) mass spectrometers with atmospheric pressure ionization (API) and traditional electron ionization (EI) for dioxin and furan analysis is emerging as a viable alternative to GC‐HRMS screening. These instruments offer greater versatility in the lab for a wider range of compound identification and quantification as well as improved ease of operation. The instruments utilized in this study included 2 API‐MS/MS, 1 traditional EI‐MS/MS, an API‐quadrupole time of flight mass spectrometer (API‐QTOF), and a EI‐high‐resolution TOF (EI‐HRTOF). This study compared these 5 instruments to a GC‐HRMS using method detection limit (MDLs) samples for dioxin and furan analysis. Each instrument demonstrated acceptable MDL values for the 17 chlorinated dioxin and furans studied. The API‐MS/MS instruments provide the greatest overall improvement in MDL value over the GC‐HRMS with a 1.5 to 2‐fold improvement. The API‐QTOF and EI‐TOF demonstrate slight increases in MDL value as compared with the GC‐HRMS with a 1.5‐fold increase. The 5 instruments studied all demonstrate acceptable MDL values with no MDL for a single congener greater than 5 times that for the GC‐HRMS. All 5 instruments offer a viable alternative to GC‐HRMS for the analysis of dioxins and furans and should be considered when developing new validated methodologies. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >使用耦合到高分辨率磁性扇形质谱仪（GC-HRMS）的气相色谱，可用于二恶英和呋喃分析。然而，使用具有大气压电离（API）和具有大气压电离（API）和传统电子电离（EI）的用于二喹啉（MS / MS）和飞行时间（TOF）和传统电子电离（EI）作为一种可行的替代品到GC-HRMS筛选。这些仪器在实验室中提供更大的多功能性，用于更广泛的复合识别和量化以及改善的操作易操作性。本研究中使用的仪器包括2 API-MS / MS，1个传统EI-MS / MS，飞行的API-QUADRUPOLE时间（API-QTOF）和EI-HEATMATE TOF（EI-HRTOF）。该研究将这5种仪器与使用方法检测限（MDLS）样品进行了用于二恶英和呋喃分析的GC-HRMS。每个仪器都表现出17个氯化二恶英和呋喃的可接受的MDL值。 API-MS / MS仪器在GC-HRM上提供最大的总体改进，GC-HRM具有1.5至2倍的改进。与GC-HRM相比，API-QTOF和EI-TOF表现出MDL值的略微增加，而GC-HRM增加，增加1.5倍。研究的5个仪器均证明可接受的MDL值，没有MDL，用于单个Congener大于GC-HRM的5倍。所有5个仪器为GC-HRM提供了可行的替代方案，用于分析二恶英和呋喃，并在开发新的验证方法时应考虑。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stultz Conner&option=202" target="_blank" rel="nofollow">Stultz Conner;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jobst Karl J.&option=202" target="_blank" rel="nofollow">Jobst Karl J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Haimovici Liad&option=202" target="_blank" rel="nofollow">Haimovici Liad;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jones Rhys&option=202" target="_blank" rel="nofollow">Jones Rhys;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Besevic Sladjana&option=202" target="_blank" rel="nofollow">Besevic Sladjana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Byer Jonathan&option=202" target="_blank" rel="nofollow">Byer Jonathan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Organtini Kari L.&option=202" target="_blank" rel="nofollow">Organtini Kari L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kolic Terry&option=202" target="_blank" rel="nofollow">Kolic Terry;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reiner Eric J.&option=202" target="_blank" rel="nofollow">Reiner Eric J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dorman Frank L.&option=202" target="_blank" rel="nofollow">Dorman Frank L.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryThe Pennsylvania State University104 Chemistry Building University Park PA 16802 USA;</p> <p>Ontario Ministry of the Environment125 Resources Road Toronto Ontario Canada M9P 3 V6;</p> <p>Ontario Ministry of the Environment125 Resources Road Toronto Ontario Canada M9P 3 V6;</p> <p>Waters CorporationStamford Avenue Altrincham Road Wilmslow SK9 4AX UK;</p> <p>Ontario Ministry of the Environment125 Resources Road Toronto Ontario Canada M9P 3 V6;</p> <p>Leco Corporation3000 Lakeview Avenue St. Joseph MI 49085 USA;</p> <p>Waters Corporation34 Maple Street Milford MA 01757 USA;</p> <p>Ontario Ministry of the Environment125 Resources Road Toronto Ontario Canada M9P 3 V6;</p> <p>Ontario Ministry of the Environment125 Resources Road Toronto Ontario Canada M9P 3 V6;</p> <p>Department of Biochemistry and Molecular BiologyThe Pennsylvania State University 107 Althouse Laboratory University ParkPA 16802 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dioxin&option=203" rel="nofollow">dioxin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mass spectrometry&option=203" rel="nofollow">mass spectrometry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=method detection limit&option=203" rel="nofollow">method detection limit;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MS/MS&option=203" rel="nofollow">MS/MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=persistent organic pollutants&option=203" rel="nofollow">persistent organic pollutants;</a> </p> <div class="translation"> 机译：二恶英;质谱;方法检测限;MS / MS;持久性有机污染物; </div> </li> </ul> </div> </div> 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analytical instrument null analysis target</a> <b>[P]</b> . <span> 外国专利：  JP4697141B2 </span> <span> . 2011-06-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：分析仪器无效分析目标中包含的分析目标材料 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130421011015.html">Pattern evaluation system evaluation target pattern determining device, evaluation target pattern determining method, and the evaluation target pattern determining program</a> <b>[P]</b> . <span> 外国专利：  JP5091620B2 </span> <span> . 2012-12-05</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：图案评价系统评价对象图案决定装置，评价对象图案决定方法以及评价对象图案决定程序 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> 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