Oxidation‐assisted structural elucidation of compounds containing a tertiary amine side chain using liquid chromatography mass spectrometry

Shamai Yamin Tamar; Prihed Hagit; Shifrovitch Avital; Dagan Shai; Weissberg Avi

摘要

Abstract > A novel analytical technique for the structural elucidation of compounds bearing a tertiary amine side chain via “in vial” instantaneous oxidation and liquid chromatography mass spectrometry (LC‐MS) was developed. A series of lidocaine homologs and benzimidazole derivatives with a major/single amine representative base peak in both their EI‐MS and ESI‐MS/MS spectra were subjected to oxidation by a 0.1% solution of hydrogen peroxide (including several 16 O/ 18 O exchange experiments), followed by LC‐ESI‐MS/MS analysis. The N‐oxide counterparts promoted extensive fragmentation with complete coverage of all parts of the molecule, enabling detailed structural elucidation and unambiguous identification of the unoxidized analytes at low nanogram per milliliter levels. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >一部小说开发了携带叔胺侧链通过“在小瓶”瞬时氧化和液相色谱质谱（LC-MS）的结构阐明的分析技术。通过0.1％的过氧化氢溶液（包括几个 16 <）对其EI-MS和EII-MS / MS光谱中的主要/单胺代表性碱基峰的一系列利多卡因同源物和苯并咪唑衍生物进行氧化（包括几个 16 < / sup> o / 18 </ sup> o交换实验），然后是LC-ESI-MS / MS分析。 N-氧化物对应物通过完全覆盖分子的完全覆盖而促进了广泛的碎片，使得能够详细的结构阐明和未氧化分析物在低纳米图中的未氧化分析物的鉴定。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shamai Yamin Tamar&option=202" target="_blank" rel="nofollow">Shamai Yamin Tamar;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prihed Hagit&option=202" target="_blank" rel="nofollow">Prihed Hagit;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shifrovitch Avital&option=202" target="_blank" rel="nofollow">Shifrovitch Avital;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dagan Shai&option=202" target="_blank" rel="nofollow">Dagan Shai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Weissberg Avi&option=202" target="_blank" rel="nofollow">Weissberg Avi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Analytical ChemistryIsrael Institute for Biological Research (IIBR)P.O.B. 19 Ness Ziona Israel;</p> <p>Department of Analytical ChemistryIsrael Institute for Biological Research (IIBR)P.O.B. 19 Ness Ziona Israel;</p> <p>Department of Analytical ChemistryIsrael Institute for Biological Research (IIBR)P.O.B. 19 Ness Ziona Israel;</p> <p>Department of Analytical ChemistryIsrael Institute for Biological Research (IIBR)P.O.B. 19 Ness Ziona Israel;</p> <p>Department of Analytical ChemistryIsrael Institute for Biological Research (IIBR)P.O.B. 19 Ness Ziona Israel;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LC‐MS/MS&option=203" rel="nofollow">LC‐MS/MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oxidation&option=203" rel="nofollow">oxidation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=structural elucidation&option=203" rel="nofollow">structural elucidation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=tertiary amine side chain&option=203" rel="nofollow">tertiary amine side chain;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=water analysis&option=203" rel="nofollow">water analysis;</a> </p> <div class="translation"> 机译：LC-MS / MS;氧化;结构阐明;叔胺侧链;水分分析; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025633319.html">Oxidation‐assisted structural elucidation of compounds containing a tertiary amine side chain using liquid chromatography mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shamai Yamin Tamar&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shamai Yamin Tamar,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prihed Hagit&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Prihed Hagit,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shifrovitch Avital&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Shifrovitch Avital,</a> <a href="/journal-foreign-34906/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of mass spectrometry: JMS .</a> <span>2018</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氧化辅助结构阐明含有液相色谱质谱法的叔胺侧链的化合物</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704014077081.html">Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry and isotope ion cluster</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Y&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liu Y,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang MM&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang MM,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xue M&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xue M,</a> <a href="/journal-foreign-34104/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of chromatography, B. 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Dancel&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Maria Cristina A. Dancel,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lolita G. Lagurin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lolita G. Lagurin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jodie V. Johnson&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jodie V. Johnson,</a> <a href="/conference-foreign-257539/" target="_blank" rel="nofollow" class="tuijian_authcolor">American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics .</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：VITEx Negundo Linn叶片的结构阐明。通过液相色谱 - 串联质谱法</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/0206150586.html">Liquid chromatography coupled with electrospray-ionization mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method development and applications for the analysis of food and medicinal herbs.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee, Kim Chung.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lee, Kim Chung. </a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱结合电喷雾电离质谱和基质辅助激光解吸/电离飞行时间质谱方法的发展及在食品和草药分析中的应用。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005922113.html">Applicability of Generic Assays Based on Liquid Chromatography–Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Timo Rousu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Timo Rousu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Juho Hokkanen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Juho Hokkanen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Olavi R. 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D.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Betowski, L. D.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jones, T. L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jones, T. L. </a> <span>1988</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：有机磷农药样品的高效液相色谱/质谱分析及高效液相色谱/质谱/质谱分析</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_food-science_thesis/020123953626.html">超声辅助提取-高相液相色谱-电感耦合等离子体质谱法测定香菇中6种形态砷化合物</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胥佳佳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 胥佳佳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯鑫&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冯鑫</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=汤静&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,汤静</a> <span> <a href="/journal-cn-9417/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 食品科学 </a> </span> <span> . 2016</span><span>,第024期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-chinese-mass-spectrometry-society_thesis/0201226252905.html">甾醇及其衍生物的质谱学规律(Ⅳ)普通饱和侧链及侧链含有环丙烷结构单元的△5-甾醇乙酸酯的质谱研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=曾志&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 曾志</a> <span> <a href="/journal-cn-8285/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 质谱学报 </a> </span> <span> . 1997</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-chromatography_thesis/0201297270455.html">新型包覆Pb纳米粒子液相色谱-串联质谱法用于鉴定沙特阿拉伯原油中的含氧化合物（英文）</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nagy E.MOUSTAFA&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Nagy E.MOUSTAFA</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kout El-Kloub Fars MAHMOUD&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Kout El-Kloub Fars MAHMOUD</a> <span> <a href="/journal-cn-14390/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 色谱 </a> </span> <span> . 2018</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_science-technology-engineering_thesis/0201258246493.html">高效液相色谱-串联质谱法对贯叶连翘中4种黄酮醇类化合物抗氧化活性的定量研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨代晓&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨代晓</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李一鸣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李一鸣</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘妍如&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘妍如</a> <span> <a href="/journal-cn-5194/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 科学技术与工程 </a> </span> <span> . 2016</span><span>,第036期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-analytical-chemistry_thesis/0201230536199.html">超高效液相色谱/高分辨质谱法测定木质素氧化降解产物中单酚类化合物</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=欧阳新平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 欧阳新平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈子龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈子龙</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邱学青&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邱学青</a> <span> <a href="/journal-cn-10804/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析化学 </a> </span> <span> . 2014</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-246_thesis/02022353137.html">液相色谱-串联质谱法检测水产品中19种全氟化合物</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HUANG Xuan-yun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . HUANG Xuan-yun</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄宣运&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄宣运</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HUANG Dong-mei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,HUANG Dong-mei</a> <span> <a href="/conference-cn-246/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2016年全国有机质谱学术会议 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313675947.html">高效液相色谱-串联质谱法测定蜂蜜中20种全氟烷基化合物</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李帅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李帅</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112642331.html">一种富集净化-液相色谱串联质谱法检测水产品中全氟烷酸化合物的方法与应用</a> <b>[P]</b> . <span> 中国专利： CN112684030A </span> <span> . 2021-04-20</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120113271507.html">一种液相色谱串联质谱法同时检测保健食品中雄激素化合物的方法</a> <b>[P]</b> . <span> 中国专利： CN113311094A </span> <span> . 2021-08-27</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130443704979.html">Elucidating the metabolism of substances, useful for investigating the degradation of pharmaceuticals, comprises analyzing substances in a liquid reaction system to identify the metabolites by liquid chromatography and mass spectrometry</a> <b>[P]</b> . <span> 外国专利：  DE10145904A1 </span> <span> . 2003-04-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：阐明物质的代谢，可用于研究药物的降解，包括在液相反应系统中分析物质，以通过液相色谱和质谱法鉴定代谢物 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130418616612.html">The computer program product which includes the computer program and that computer program which execute method and that method of processing the mass spectrometry data, being the method of processing the mass spectrometry data which possesses the liquid chromatography mass spectrometry machine null periodic signal which includes the fourier transform mass spectrometry machine which includes the data processing expedient which executes</a> <b>[P]</b> . <span> 外国专利：  JP5562933B2 </span> <span> . 2014-07-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包括执行该程序和该处理质谱数据的方法的计算机程序和该计算机程序的计算机程序产品是具有包括傅立叶的液相色谱质谱仪无效周期信号的质谱数据的处理方法。包括执行数据处理权宜之计的变换质谱仪 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130420620450.html">LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY DEVICE AND ANALYSIS METHOD USING LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY DEVICE</a> <b>[P]</b> . <span> 外国专利：  US2012306883A1 </span> <span> . 2012-12-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱/质谱联用装置及使用该液相色谱/质谱联用装置的分析方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025633319','4',7,2,1,'',this,24)" class="delivery" prompt="010401" 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