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首页> 外文期刊>Journal of Applied Phycology >Antidiabetic and antioxidant activities of brown and red macroalgae from the Persian Gulf
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Antidiabetic and antioxidant activities of brown and red macroalgae from the Persian Gulf

机译:来自波斯湾的棕色和红色大草原的抗糖尿病和抗氧化活性

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摘要

The inhibition of pancreatic alpha-amylase and the prevention of pancreatic oxidative damage are considered possible strategies for the management of type 2 diabetes. The aim of our study was to evaluate in vitro the antioxidant properties and alpha-amylase inhibition of ten brown and red macroalgal species from the Persian Gulf. The alpha-amylase inhibition was tested using the chromogenic dinitrosalicylic acid (DNS) method, and the antioxidant properties were evaluated using the ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) radical scavenging and ferric reducing antioxidant power (FRAP) methods. The results of our study showed that all analyzed macroalgal species revealed antioxidant effects and alpha-amylase inhibitory activities. Among the studied species, the highest alpha-amylase inhibition was shown by the brown algae Sirophysalis trinodis (IC50 0.42 mg mL(-1), 32-97% inhibition), Polycladia myrica (IC50 = 0.72 mg mL(-1), 32-97% inhibition), and the red alga Palisada perforata (IC50 = 1.1 mg mL(-1), 27-91%). Sirophysalis trinodis (125.4 mu g ASA mg(-1)) and Sargassum angustifolium (IC50 = 0.40 mg mL(-1)) had the highest FRAP-reducing power and ABTS radical scavenging activities, respectively. In addition to the species, alpha-amylase inhibition and the antioxidant effects depended on the type of solvent used for algal extraction; the best properties were generally presented by methanol and ethyl acetate. In conclusion, the enzyme inhibition and antioxidant activities of S. trinodis, P. myrica, P. perforata, and S. angustifolium suggest that they may have potential for antidiabetic and antioxidant use and could therefore be studied further for potential pharmaceutical use.
机译:胰腺α-淀粉酶的抑制和预防胰腺氧化损伤被认为是2型糖尿病的可能策略。我们的研究目的是从波斯湾中评估体外抗氧化性能和α-淀粉酶抑制10种棕色和红色大草蛋白物种。使用发色素二硝基水杨酸(DNS)方法测试α-淀粉酶抑制,并使用ABTS(2,2'-唑苯基 - 双(3​​-乙基苯并噻唑啉-6-磺酸))评价抗氧化性能)自由基清除和铁减少抗氧化功率(FRAP)方法。我们的研究结果表明,所有分析的大类物种都揭示了抗氧化效应和α-淀粉酶抑制活性。在研究的物种中,棕榈藻肌肌醇三孔(IC50 0.42mg ml(-1),32-97%抑制),Polycladia myrica(IC50 = 0.72mg ml(-1),32,最高α-淀粉酶抑制-97%抑制),红色藻类Palisada perforata(IC50 = 1.1mg ml(-1),27-91%)。 Sirophysalis Trinodis(125.4μgASA mg(-1))和Sargassum angustifolium(IC50 = 0.40mg ml(-1))分别具有最高的压缩功率和ABTS自由基清除活性。除了物种外,α-淀粉酶抑制和抗氧化效果依赖于用于藻类萃取的溶剂类型;通常通过甲醇和乙酸乙酯呈现最佳性质。总之,S. Trinodis,P. myrica,P.Pervorata和S.Angustifolium的酶抑制和抗氧化活性表明它们可能具有抗糖尿病和抗氧化剂使用的潜力,因此可以进一步研究潜在的药物用途。

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