Synthesis of acyl thiourea derivatives of 7-trifluoromethyl-2-pyridylquinazolin-4(3H)-one as anticancer agents

摘要

A new series of 7-trifluoromethyl-2-pyridylquinazolin-4(3H)-one-based acyl thiourea derivatives has been generated and tested for their cytotoxicity towards human ovarian cancer (SK-OV-3), cervical cancer (HeLa), renal cancer (Caki-2) cell lines, as well as noncancerous a human umbilical vein endothelial cell (HUVEC) line. The new thiourea derivatives were found to be promisingly cytotoxic towards the cancerous cell lines. Changing the substituent at the thiourea linkage led to variations in the cytotoxic potential of the resultant derivatives towards specific cell lines. Molecules with fluorine functionality and multiple pyridyl moieties showed encouraging anticancer effects and could be used as a platform for the design of further chemotherapeutic agents. The proposed structures of the products were ascertained through FTIR, mass, H-1 NMR and C-13 NMR spectra and elemental analyses.