An expeditious one-pot synthesis of pyrido[2,3-d]pyrimidines using Fe3O4-ZnO-NH2-PW12O40 nanocatalyst

摘要

An efficient protocol for the facile synthesis of a series of pyrido[2,3-d]pyrimidine derivatives has been developed applying Fe3O4-ZnO-NH2-PW12O40 nanocatalyst in water. This novel method has the benefits of operational simplicity, green aspects by avoiding toxic solvents and high to excellent yields of products. Fe3O4-ZnO-NH2-PW12O40 was synthesized and characterized by Fourier transform infrared, X-ray diffraction, vibrating sample magnetometer, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy analyses. The nanocatalyst is readily isolated and recovered from the reaction mixture by an external magnet.