1-PHENYL-3- (HETEROARYLALKYL) PYRIDO (2,3-d) PYRIMIDINE-2,4- (1H, 3H)-DIONE AND PYRIDO £2,3-d PYRIMIDINE-2- (1H, 3H)-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to optionally substituted pyrido-[2,3-d]-pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido-[2,3-d]-pyrimidine-2(1H,3H)-ones, particularly to 1-(optionally substituted) phenyl-3-(optionally substituted heteroarylalkyl or arylalkyl)-pyrido-[2,3-d]pyrimidine-2,4(1H,3H)-diones and pyrido-[2,3-d]-pyrimidine-2(1H,3H)-ones, useful as anti-inflammatory agents, immunosuppressive agents, anti-allograft rejection agents, anti-graft-vs-host disease agents, anti-allergic agents (e.g., asthma, rhinitis and atopic dermatitis), anti-autoimmune agents or analgetic agents, to their precursors, to their preparation and to pharmaceutical compositions using the compounds of the invention.