MRI-CEST imaging of tumor metabolism and acidosis for characterizing murine tumor aggressiveness

摘要

Cancer metabolism is routinely assessed by the quantification of the FDG uptake by PET imaging, despite radiation exposure issues and reduced spatial resolution that limits heterogeneity assessment. The aim of this study was to exploit radiation- free MRI-CEST (Chemical Exchange Saturation Transfer) methods for investigating different aspect of tumour metabolism, including dysregulated glucose uptake following the injection of natural D-glucose[1] or of 3-O-Methyl-D-glucose [2] and tumor acidosis following iopamidol administration [3] in two murine models exhibiting distinct metabolic rate.