SIRT3 is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis Mitochondrial Tumor Suppressor. Revision

摘要

The incidence of human malignancies increases significantly with age, suggesting a mechanistic connection between aging (longevity) and carcinogenesis Breast malignancies that develop with increasing age very likely represent a spectrum of cancers arising from different types of hereditary and spontaneous tumors. Murine models for hereditary breast cancer in younger women have been established by altering the expression of BRCA genes. In contrast, there are no murine models for the spontaneous breast cancers that are more common in older women. The work supported by this DOD idea award has allows us to not only validate the first ER+ in vivo murine model for breast cancers but is has also allowed the discovery of several potential molecular targets that may potential be used for either chemoprevention or as anticancer agents.