Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

Nishiya Yumi; Suzuki Eiko; Ishizuka Tomoko; Kazui Miho; Sakurai Hidetaka; Nakai Daisuke

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Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

机译：鉴定涉及新药代谢的非P450酶：它们对药物相互作用评估和前药置剂的意义

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来源
《Trends in Ecology & Evolution》 |2020年第1期|共11页
作者
Nishiya Yumi; Suzuki Eiko; Ishizuka Tomoko; Kazui Miho; Sakurai Hidetaka; Nakai Daisuke;
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作者单位

Daiichi Sankyo Co Ltd Drug Metab &

Pharmacokinet Res Labs Tokyo Japan;

Daiichi Sankyo Co Ltd Drug Metab &

Pharmacokinet Res Labs Tokyo Japan;

Daiichi Sankyo Co Ltd Clin Pharmacol Dept Tokyo Japan;

Daiichi Sankyo Co Ltd Drug Metab &

Pharmacokinet Res Labs Tokyo Japan;

Daiichi Sankyo RD Novare Co Ltd Gen Adm Dept Tokyo Japan;

Daiichi Sankyo Co Ltd Biomarker &

Translat Res Dept Tokyo Japan;

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原文格式 PDF
正文语种 eng
中图分类数学生态学与生物模型;
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专利

1. Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition [J] . Nishiya Yumi, Suzuki Eiko, Ishizuka Tomoko, Trends in Ecology & Evolution . 2020,第1期

机译：鉴定涉及新药代谢的非P450酶：它们对药物相互作用评估和前药置剂的意义
2. Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug–drug interaction [J] . Qu Wei, Liu Xuezheng Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2018,第4期

机译：鉴定涉及阿尔科普素代谢的细胞色素P450同种型及其药物 - 药物互动评估
3. Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug–drug interaction [J] . Qu Wei, Liu Xuezheng Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2018,第4期

机译：鉴定涉及阿尔科普素代谢的细胞色素P450同种型及其药物 - 药物互动评估
4. ANALYTICAL STRATEGIES TO EVALUATE THE ACTIVITY OF NINE MAJOR CYP450 ENZYMES INVOLVED IN DRUG METABOLISM BY LIQUID CHROMATOGRAPHY-QUADRUPOLE MASS SPECTROMETRY [C] . Maxim Maheux, Claude-Paul Lafrance American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：液相色谱 - 四极孔质谱法评价九个主要CYP450酶活性的分析策略
5. Improvement of gastroparesis management by addressing challenges in drug metabolism: Studies with metabolite identification, reaction phenotyping and in vitro drug-drug interactions. [D] . Youssef, Amir S. 2013

机译：通过应对药物代谢方面的挑战来改善胃轻瘫的管理：有关代谢物鉴定，反应表型和体外药物相互作用的研究。
6. Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone a potent new oral antiarrhythmic drug [O] . Sylvie Klieber, Catherine Arabeyre-Fabre, Patricia Moliner, 2014

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7. Identification of Human P450 Isoforms Involved in the Metabolism of the Antiallergic Drug, Oxatomide, and Its Inhibitory Effect on Enzyme Activity [O] . Akihisa Goto, Yasuhisa Adachi, Atsuhiro Inaba, 2004

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8. Identification of Novel Inhibitory Peptides of Protein-Protein Interactions Involved in DNA Repair as Potential Drugs in Breast Cancer Treatment [R] . Kamalakaran, S. 2005

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Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

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