Inhibition of I-Kr potentiates development of atrial-selective I-Na block leading to effective suppression of atrial fibrillation

Burashnikov Alexander; Belardinelli Luiz; Antzelevitch Charles

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Inhibition of I-Kr potentiates development of atrial-selective I-Na block leading to effective suppression of atrial fibrillation

机译：抑制I-Kr增强的心房选择性I-Na块的发育，导致心房颤动的有效抑制

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摘要

BACKGROUND The availability of safe and effective drugs for the management of atrial fibrillation (AF) remains an unmet medical need.

机译：背景技术用于管理心房颤动（AF）的安全和有效药物的可用性仍然是未满足的医疗需求。

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来源
《Heart rhythm: the official journal of the Heart Rhythm Society》 |2015年第4期|共9页
作者
Burashnikov Alexander; Belardinelli Luiz; Antzelevitch Charles;
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作者单位

Masonic Med Res Lab Utica NY 13501 USA;

Gilead Sci Inc Foster City CA 94404 USA;

Masonic Med Res Lab Utica NY 13501 USA;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Electrophysiology; Pharmacology; Antiarrhythmic drugs; Lidocaine; Atrial fibrillation;

机译：电生理;药理学;抗心律失常药物;利多卡因;心房颤动;

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1. Inhibition of I-Kr potentiates development of atrial-selective I-Na block leading to effective suppression of atrial fibrillation [J] . Burashnikov Alexander, Belardinelli Luiz, Antzelevitch Charles Heart rhythm: the official journal of the Heart Rhythm Society . 2015,第4期

机译：抑制I-Kr会增强房选择性I-Na阻滞的发展，从而有效抑制房颤
2. Atrial-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation [J] . Alexander Burashnikov, Jose M. di Diego, Andrew C. Zygmunt, Annals of the New York Academy of Sciences . 2008,第期

机译：心房选择性钠通道阻滞作为抑制心房颤动的策略
3. Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation [J] . BurashnikovA., PetroskiA., HuD., Heart rhythm: the official journal of the Heart Rhythm Society . 2012,第1期

机译：Wenxin Keli选择性抑制钠通道电流可有效抑制心房纤颤
4. Atrial-Selective Sodium Channel Blockas a Strategy for Suppressionof Atrial Fibrillation [C] . ALEXANDER BURASHNIKOV, JOSEM.DI DIEGO, ANDREWC.ZYGMUNT, Larry Horti Fairberg Workshop on Control and Regulation of Transport Phenomena in Biological Systems with Special Emphasis on the Cardiac System . 2008

机译：心房选择性钠通道阻止了一种抑制心房颤动的策略
5. Estimating Effective Dose from Phantom Dose Measurements in Atrial Fibrillation Ablation Procedures and Comparison of MOSFET and TLD Detectors in a Small Animal Dosimetry Setting. [D] . Anderson-Evans, Colin David. 2011

机译：在小型动物剂量测定环境中，根据心房纤颤消融手术中幻影剂量测量值估算有效剂量，并比较MOSFET和TLD检测器。
6. Atrial-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation [O] . Alexander Burashnikov, José M. di Diego, Andrew C. Zygmunt, -1

机译：心房选择性钠通道阻滞作为抑制心房颤动的策略
7. Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation [O] . Alexander Burashnikov, Alyssa Petroski, Dan Hu, 2012

机译：温鑫keli对钠通道电流的心房选择性抑制在抑制心房颤动方面是有效的

Inhibition of I-Kr potentiates development of atrial-selective I-Na block leading to effective suppression of atrial fibrillation

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