Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

Tameris Michele; Mearns Helen; Penn-Nicholson Adam; Gregg Yolande; Bilek Nicole; Mabwe Simbarashe; Geldenhuys Hennie; Shenje Justin; Luabeya Angelique Kany Kany; Murillo Ingrid; Doce Juana; Aguilo Nacho; Marinova Dessislava; Puentes Eugenia; Rodriguez Esteban; Gonzalo-Asensio Jesus; Fritzell Bernard; Thole Jelle; Martin Carlos; Scriba Thomas J.; Hatherill Mark

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Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

机译：活衰减的分枝杆菌疫苗MTBVAC与BCG在成人和新生儿中：随机控制，双盲剂量升级试验

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Background Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high.

机译：背景婴儿是新结核病疫苗的关键目标群体。我们评估了在成人和婴儿在结核病的地区的成人和婴儿中的活衰减的分枝杆菌疫苗候选MTBVAC的安全性和免疫原性。

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《The lancet. Respiratory medicine.》 |2019年第9期|共14页
作者
Tameris Michele; Mearns Helen; Penn-Nicholson Adam; Gregg Yolande; Bilek Nicole; Mabwe Simbarashe; Geldenhuys Hennie; Shenje Justin; Luabeya Angelique Kany Kany; Murillo Ingrid; Doce Juana; Aguilo Nacho; Marinova Dessislava; Puentes Eugenia; Rodriguez Esteban; Gonzalo-Asensio Jesus; Fritzell Bernard; Thole Jelle; Martin Carlos; Scriba Thomas J.; Hatherill Mark;
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作者单位

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Biofabri Pontevedra Spain;

Biofabri Pontevedra Spain;

Univ Zaragoza Fac Med Dept Microbiol Zaragoza Spain;

Univ Zaragoza Fac Med Dept Microbiol Zaragoza Spain;

Biofabri Pontevedra Spain;

Biofabri Pontevedra Spain;

Univ Zaragoza Fac Med Dept Microbiol Zaragoza Spain;

TB Vaccine Initiat Lelystad Netherlands;

TB Vaccine Initiat Lelystad Netherlands;

Univ Zaragoza Fac Med Dept Microbiol Zaragoza Spain;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

Univ Cape Town South African TB Vaccine Initiat Inst Infect Dis &

Mol Med Cape Town South Africa;

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正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial [J] . Tameris Michele, Mearns Helen, Penn-Nicholson Adam, The lancet. Respiratory medicine. . 2019,第9期

机译：活衰减的分枝杆菌疫苗MTBVAC与BCG在成人和新生儿中：随机控制，双盲剂量升级试验
2. Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial (vol 16, pg 31, 2016) [J] . The Lancet infectious diseases . 2016,第1期

机译：ChAd3-EBO-Z埃博拉病毒疫苗在马里和美国成年人中的使用，以及用MVA-BN-Filo增强马来成年人的免疫力：1期，单盲，随机试验，1b期，开放标签和双盲，剂量递增试验和嵌套，随机，双盲，安慰剂对照试验（2016年第16卷，第31页）
3. Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial [J] . Spertini Francois, Audran Regine, Chakour Reza, The lancet. Respiratory medicine. . 2015,第12期

机译：用减毒活结核分枝杆菌疫苗进行人类免疫的安全性：一项随机，双盲，对照I期试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Comparison of the efficacy of intranasal versus subcutaneous bacillus calmette-guerin (BCG) vaccination against challenge with virulent Mycobacterium tuberculosis. [D] . Uppari, Sridhar. 2012

机译：鼻内和皮下卡介苗（BCG）接种疫苗对抗强力结核分枝杆菌攻击的功效比较。
6. Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults and boosting of Malian adults with MVA-BN-Filo: a phase 1 single-blind randomised trial a phase 1b open-label and double-blind dose-escalation trial and a nested randomised double-blind placebo-controlled trial [O] . Milagritos D Tapia, Samba O Sow, Kirsten E Lyke, -1

机译：ChAd3-EBO-Z埃博拉病毒疫苗在马里和美国成年人中的使用以及用MVA-BN-Filo加强马来成年人的免疫：一项1期单盲随机试验1b期开放标签和双盲剂量递增试验以及嵌套随机双盲安慰剂对照试验
7. Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial [O] . Tapia Milagritos D, Sow Samba O, Lyke Kirsten E, 2016

机译：ChAd3-EBO-Z埃博拉病毒疫苗在马里和美国成年人中的使用，以及用MVA-BN-Filo加强马来成年人的免疫：一项1期，单盲，随机试验，1b期，开放标签和双盲，剂量递增试验和嵌套，随机，双盲，安慰剂对照试验

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

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