Intake of total cruciferous vegetable and its contents of glucosinolates and isothiocyanates, glutathioneS-transferases polymorphisms and breast cancer risk: a case-control study in China

摘要

Cruciferous vegetables contain high levels of glucosinolates (GSL) and isothiocyanates (ITC). ITC are known to induce glutathioneS-transferases (GST) and thus exert their anticarcinogenic effects. This study explored the combined effects of cruciferous vegetable, GSL and ITC intake andGSTpolymorphisms on breast cancer risk. A total of 737 breast cancer cases and 756 controls were recruited into this case-control study. OR and 95 % CI were assessed by multivariable logistic regression. Higher cruciferous vegetable, GSL and ITC intakes were inversely associated with breast cancer risk, with adjusted OR of 0 center dot 48 (95 % CI 0 center dot 35, 0 center dot 65), 0 center dot 54 (95 % CI 0 center dot 40, 0 center dot 74) and 0 center dot 62 (95 % CI 0 center dot 45, 0 center dot 84), respectively. Compared with women carrying theGSTP1rs1695 wild AA genotype and high cruciferous vegetable, GSL or ITC intake, carriers of the AA genotype with low cruciferous vegetable, GSL and ITC intake had greater risk of breast cancer, with adjusted OR of 1 center dot 43 (95 % CI 1 center dot 01, 1 center dot 87), 1 center dot 34 (95 % CI 1 center dot 02, 1 center dot 75) and 1 center dot 37 (95 % CI 1 center dot 05, 1 center dot 80), respectively. Persons with theGSTM1-null genotype and lower intake of cruciferous vegetables, GSL and ITC had higher risk of breast cancer than those with theGSTM1-present genotype and higher intake, with OR of 1 center dot 42 (95 % CI 1 center dot 04, 1 center dot 95), 1 center dot 43 (95 % CI 1 center dot 05, 1 center dot 96) and 1 center dot 45 (95 % CI 1 center dot 06, 1 center dot 98), respectively. Among women possessing theGSTT1-present genotype, low intake of cruciferous vegetables, GSL or ITC was associated with higher risk of breast cancer. But these interactions were non-significant. This study indicated that there were no significant interactions between cruciferous vegetable, GSL or ITC intake andGSTpolymorphisms on breast cancer risk.