Development of psoriasis in IBD patients under TNF-antagonist therapy is associated neither with anti-TNF-antagonist antibodies nor trough levels

摘要

Background: The cause of anti-TNF-induced psoriasis is still unknown.Objective: We aimed to evaluate if the appearance of psoriasis under anti-TNF therapy is associated with anti-TNF antibody levels and TNF-antagonist trough levels.Methods: In this case-control study we identified 23 patients (21 with Crohn's disease [CD], two with ulcerative colitis [UC]) who developed psoriasis under infliximab (IFX, n=20), adalimumab (ADA, n=2), and certolizumab pegol (CZP, n=1) and compared them regarding the anti-TNF-antagonist antibody levels with 85 IBD patients (72 with CD, 13 with UC) on anti-TNF therapy without psoriasis.Results: Median disease duration was not different between the two groups (7 years in the group with psoriasis under TNF-antagonists vs. 10 years in the control group, p=0.072). No patient from the psoriasis group had antibodies against TNF-antagonists compared to 10.6% in the control group (p=0.103). No difference was found in IFX trough levels in the group of patients with psoriasis compared to the control group (2.6g/mL [IQR 0.9-5.5] vs. 3.4g/mL [IQR 1.4-8.1], p=0.573). TNF-antagonist therapy could be continued in 91.3% of patients with TNF-antagonist related psoriasis and most patients responded to topical therapies.Conclusion: Anti-TNF-induced psoriasis seems to be independent of anti-TNF antibodies and trough levels. Interruption of Anti-TNF therapy is rarely necessary.