Synthesis of N-Methylpiperidin-4-one Derivatives and Evaluation of Their Anti-Endometrial Cancer Activity

摘要

Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl-and 3-cyanophenyl-substituted derivatives.