Oxidative C-O coupling as a new idea in the 'click-like chemistry': malonyl peroxides for the conjugation of two molecules

摘要

Malonyl peroxides were used for the one-pot construction of hybrid structures by conjugation of heterocycle (3H-pyrazol-3-one, isoxazol-5(2H)-one, pyrazolidine-3,5-dione, or barbituric acid) and amine or alcohol. The first stage represents oxidative C-O coupling with liberation of the carboxyl group which is functionalized at the second stage thus affording 'click-like' products with malonic linker.