摘要:Objective:Chooses two chlorinated paraffins products which contain different con-tent of short chain chlorinated paraffins(SCCP)as model compound(CPsⅠ,38.22% and CPsⅡ, 0.08%),compares their influence on SD male rats after continuously 14 days being exposed through oral intragastric administration,according to that,to explore whether there is special toxicity of SC-CP or not. Methods:The exposing concentration are 10,50,100(CPsⅠ),100(CPsⅡ)mg/kg,re-spectively. Results:After being exposed under two chlorinated paraffins,there is no obvious influ-ence on food intaking and weight. CPsⅠand CPsⅡ acute exposing,can cause hepatocyte swelling, hydropic degeneration,cytoplast loosen;and renal tubule swelling,glomerulus atrophy,glomerulus hyalinosis;and alveolar septum incrassation,inflammatory cell infiltration;and so on histopatholo-gy changes. Conclusion:Acute chlorinated paraffines exposing has toxicity to SD male rats,the ef-fect has no significant relationship with the content of SCCP.%目的:选择短链氯化石蜡含量不同的两种氯化石蜡产品(CPsⅠ,38.22%和CPsⅡ,0.08%)作为模式化合物,比较它们经口连续灌胃暴露14 d后对SD雄性大鼠的影响,借以探讨短链氯化石蜡是否存在特殊的毒性效应。方法:CPsⅠ和CPsⅡ的暴露浓度分别为10、50、100 mg/kg(CPsⅠ)和100 mg/kg (CPsⅡ)。结果:两种氯化石蜡产品暴露后,对大鼠的摄食、体重无明显影响。CPsⅠ和CPsⅡ急性暴露,均可造成大鼠的肝脏中肝细胞肿胀、水样变性及胞质疏散;肾脏中肾小管肿胀,肾小球萎缩、肾小球玻璃样变;肺部中肺泡隔增厚,炎症细胞浸润等明显的组织病理学改变。结论:氯化石蜡急性暴露对SD雄性大鼠所产生的毒性效应,与样品中短链氯化石蜡的含量并无显著性关联。