Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments

Ponomarev Konstantin; Morozova Ekaterina; Pavlova Alla; Suslov Evgeniy; Korchagina Dina; Nefedov Andrej; Tolstikova Tatyana; Volcho Konstantin; Salakhutdinov Nariman

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Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments

机译：二氮酰胺和单萜片段组合胺的合成与镇痛活性

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摘要

Background: It was found earlier that compounds combining diazaadamantane and monoterpene moieties possessed promising analgesic activity along with low acute toxicity and the lack of ulcerogenic activity.

机译：背景：早期发现，结合DiazaAdamantane和单萜部分的化合物具有有前途的镇痛活动以及低急性毒性和缺乏溃疡性活性。

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来源
《Medicinal chemistry》 |2017年第8期|共7页
作者
Ponomarev Konstantin; Morozova Ekaterina; Pavlova Alla; Suslov Evgeniy; Korchagina Dina; Nefedov Andrej; Tolstikova Tatyana; Volcho Konstantin; Salakhutdinov Nariman;
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作者单位

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

Russian Acad Sci Siberian Branch NN Vorozhtsov Novosibirsk Inst Organ Chem Novosibirsk 630090;

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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Monoterpene; azaadamantane; adamantane; heterocyclic compounds; analgesic activity; acetic acid-induced writhing test; hot plate test;

机译：单萜;AzaAdamantane;金刚烷;杂环化合物;镇痛活动;醋酸诱导的扭曲试验;热板测试;

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1. Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments [J] . Ponomarev Konstantin, Morozova Ekaterina, Pavlova Alla, Medicinal chemistry . 2017,第8期

机译：二氮酰胺和单萜片段组合胺的合成与镇痛活性
2. Anti-influenza activity of diazaadamantanes combined with monoterpene moieties [J] . Evgeniy Suslov, Vladimir V. Zarubaev, Alexander V. Slita, Bioorganic and Medicinal Chemistry Letters . 2017,第19期

机译：二聚酰胺烷烃的抗流感活性联合单萜部分
3. Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties [J] . Ponomarev Konstantin, Pavlova Alla, Suslov Evgeniy, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2015,第12期

机译：氮杂金刚烷和单萜部分的新化合物的合成和止痛活性
4. Synthesis, Characterization and Biological Activity of Flavonoid Derivatives with Amine [C] . Sheetal Shrimal, Anamika Jain National Conference on Physics and Chemistry of Materials . 2019

机译：黄酮衍生物与胺的合成，表征及生物活性
5. Diaziridinium Ions: First Reported Synthesis and Reactivity Studies. Tropylium Ion Mediated alpha-Cyanation of Amines. Multicatalytic Synthesis of Complex Tetrahydrofurans. [D] . Allen, Julia Margaret. 2011

机译：二叠氮鎓离子：首次报道的合成和反应性研究。 Tropylium离子介导的胺的α-氰化。复杂的四氢呋喃的多催化合成。
6. Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines [O] . Rachel Grainger, Tom D. Heightman, Steven V. Ley, 2019

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7. Synthesis and analgesic activity of C-terminal fragment peptides of cholecystokinin. [O] . KOJI IUCHI, MASAHIRO NITTA, TAKASHI TANAKA, 1987

机译：胆囊苷蛋白C-末端片段肽的合成与镇痛活性。

Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments

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