Brinzolamide–brimonidine fixed combination for the prevention of intraocular pressure elevation after phacoemulsification

摘要

Aim: To evaluate the effectiveness of brinzolamide–brimonidine fixed combination to control the intraocular pressure elevation throughout the first 24?h following uncomplicated phacoemulsification cataract surgery. Patients and Methods: A total of 62 patients who underwent phacoemulsification cataract surgery were included in this prospective randomized comparative case series. The brinzolamide–brimonidine fixed combination group (34 eyes) was administered a single dose of brinzolamide–brimonidine fixed combination immediately after phacoemulsification. No treatment was administered in the control group (28 eyes). Intraocular pressure was measured 1?day before surgery (baseline) and at 6, 12 and 24?h postoperatively. Results: The brinzolamide–brimonidine fixed combination group had significantly lower intraocular pressure at 6, 12 and 24?h after phacoemulsification compared to baseline (p?