CREM variant rs1 7583959 conferred susceptibility to T1D risk in the Tunisian families

摘要

Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of insulin producing pancreatic beta-cells by autoreactive T cells. Studies in animal models, such as the non-obese diabetic (NOD) mouse reveal that this disease is under the control of several genes that encode molecules implicated in regulation of transcription factors and in T cell activation. In order to underline the role of the genes involved in this regulation pathways, we investigated, using the Sequenom MassARRAY platform, 13 single-nucleotide polymorphisms (SNPs) belonging to CREM, IRF5, STAT4, and STAT5a/b genes in 59 T1 D Tunisian families.