New Genetic Variants Are Associated with Breast Cancer Susceptibility Aggressiveness in the Tunisian Population

摘要

Most late-onset cases occur in the absence of a first-degree family history of breast cancer and are often called "sporadic" cases. Single nucleotide polymorphisms (SNPs) may be causally related to breast cancer risk or be indirectly associated with breast cancer risk through linkage disequilibrium with a causal sequence variant. Risk-associated SNPs will have different frequencies among women with or without breast cancer and can be detected using genetic association studies. Recently, several genome-wide association studies (GWAS) have identified novel risk alleles for breast cancer including those related to FGFR2, TNRC9, MAP3K1, LSP1 genes and other locus [1, 2]. Replication in independent population samples is essential for validation of the results of any genome-wide association. Since the genetic variants (SNPs) are common, they are likely to be shared across different populations with diverse ancestry backgrounds. It would be of interest to determine and investigate the potential implications of these novel markers revealed by genome-wide association studies to predict the "sporadic" breast cancer risk and progression in MENA populations.