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首页> 外文期刊>Environmental microbiology >Transcriptomic investigation into polyketide toxin synthesis in OstreopsisOstreopsis (Dinophyceae) species
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Transcriptomic investigation into polyketide toxin synthesis in OstreopsisOstreopsis (Dinophyceae) species

机译：转录组中的血液毒素在鸵鸟血红素合成中的研究 - 鸵鸟（Dinophyceae）物种

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Summary > In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth. Their ecological success may be related to their production of complex toxic polyketide compounds. Ostreopsis species produce potent palytoxin‐like compounds (PLTX), which are associated with human skin and eye irritations, and illnesses through the consumption of contaminated seafood. To investigate the genetic basis of PLTX‐like compounds, we sequenced and annotated transcriptomes from two PLTX‐producing Ostreopsis species; O . cf. ovata , O . cf. siamensis , one non‐PLTX producing species, O . rhodesae and compared them to a close phylogenetic relative and non‐PLTX producer, Coolia malayensis . We found no clear differences in the presence or diversity of ketosynthase and ketoreductase transcripts between PLTX producing and non‐producing Ostreopsis and Coolia species, as both groups contained 90 and ?10 phylogenetically diverse ketosynthase and ketoreductase transcripts, respectively. We report for the first‐time type I single‐, multi‐domain polyketide synthases (PKSs) and hybrid non‐ribosomal peptide synthase/PKS transcripts from all species. The long multi‐modular PKSs were insufficient by themselves to synthesize the large complex polyether backbone of PLTX‐like compounds. This implies that numerous PKS domains, including both single and multi‐, work together on the biosynthesis of PLTX‐like and other related polyketide compounds. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <title类型=“main”>摘要</ title> >在海洋生态系统中，Dinoflagellates有时会变得非常丰富，甚至是甚至在次数中，尽管他们相对缓慢生长。它们的生态成功可能与其生产复杂有毒聚酮化合物的生产有关。 鸵鸟（Ostreopsis </ i>物种产生有效的甲状腺毒素样化合物（PLTX），其与人体皮肤和眼睛刺激性相关，以及通过污染的海鲜消耗的疾病。为了探讨PLTX样化合物的遗传基础，我们测序和注释从两种PLTX产生的转录瘤血蚊剂</ i>物种; o </ i>。 CF. ovata </ i>， o </ i>。 CF. Siamensis </ i>，一个非PLTX生产物种， o </ i>。 rhodesae </ i>并将它们与紧密的系统发育相对和非PLTX生产商进行比较， Coolia Malayensis </ i>。我们发现在PLTX生产和非生产之间的酮皂酶和酮还原酶转录物的存在或多样性没有明确差异，并且由于这两个组和GT; 90和＆gt ; 10分别为10个系统血糖均多的酮糖酶和酮还原酶转录物。我们向所有物种的第一次型I，多域聚酮二酮合成酶（PKS）和杂化非核糖体肽合酶/ PKS转录物报告。长度多模块化PKS本身不足以合成PLTX样化合物的大型复合聚醚骨架。这意味着许多PKS结构域，包括单一和多重，在PLTX样和其他相关聚酮化合物的生物合成上工作。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Verma Arjun&option=202" target="_blank" rel="nofollow">Verma Arjun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kohli Gurjeet S.&option=202" target="_blank" rel="nofollow">Kohli Gurjeet S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Harwood D. Tim&option=202" target="_blank" rel="nofollow">Harwood D. Tim;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ralph Peter J.&option=202" target="_blank" rel="nofollow">Ralph Peter J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Murray Shauna A.&option=202" target="_blank" rel="nofollow">Murray Shauna A.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Climate Change Cluster University of Technology SydneyUltimo New South Wales 2007 Australia;</p> <p>Climate Change Cluster University of Technology SydneyUltimo New South Wales 2007 Australia;</p> <p>Cawthron Institute 98Halifax Street East Nelson 7010 New Zealand;</p> <p>Climate Change Cluster University of Technology SydneyUltimo New South Wales 2007 Australia;</p> <p>Climate Change Cluster University of Technology SydneyUltimo New South Wales 2007 Australia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_agricultural-science-technology_thesis/0201275446533.html">正常雏鸵鸟与患腿病雏鸵鸟胫骨内部结构差异研究</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王蕾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">王蕾,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭克美&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">彭克美,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程佳月&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">程佳月,</a> <a href="/journal-foreign-7295/" target="_blank" rel="nofollow" class="tuijian_authcolor">农业科学与技术（英文版） .</a> <span>2013</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_agricultural-science-technology_thesis/0201268780327.html">正常雏鸵鸟与患腿病雏鸵鸟胫骨内部结构差异研究（英文）</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王蕾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">王蕾,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭克美&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">彭克美,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程佳月&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">程佳月,</a> <a href="/journal-foreign-7295/" target="_blank" rel="nofollow" class="tuijian_authcolor">农业科学与技术：英文版 .</a> <span>2013</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023228594.html">Transcriptomic investigation into polyketide toxin synthesis in <i >OstreopsisOstreopsis (Dinophyceae) species</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Verma Arjun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Verma Arjun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kohli Gurjeet S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kohli Gurjeet S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Harwood D. 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