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Development of Electrochemical Sensor Based on Glassy Carbon Electrode Modified with a Molecularly Imprinted Copolymer and its Application for Detection of Repaglinide

机译:基于玻碳碳电极的电化学传感器改性用分子印迹共聚物改性的电化学传感器及其检测检测

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Abstract >At the present study, we have reported a new sensor based on immobilized molecularly imprinted polymer on the surface of a glassy carbon electrode (GCE) through electro polymerization of o‐Dihydroxybenzene (o‐DB) and o‐phenylenediamine (o‐PD) as monomers for direct determination of repaglinide (RPG) as target molecule. RPG is a new generation of oral anti‐diabetic drugs that has a rapid onset of action and short half‐life of approximately 1?h. So developing a controlled system with good sensitivity and selectivity is required to eliminate its adverse effects. Under the optimized conditions, the proposed sensor showed a good selectivity to detect RPG among compounds with similar structure and properties with RPG. The linear range for analysis were 0.005–1.0?μM and detection limit 1.8?nM was achieved. Furthermore, the experimental results showed that the proposed sensor was highly selective and sensitive to detect RPG in real samples such as blood serum, urine and RPG tablet. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译:</span><abstract type =“main”xml:lang =“en”> <title type =“main”>抽象</ title> >在本研究中,我们报告了一种基于固定的分子印迹聚合物的新传感器通过O-二羟基苯(O-DB)和O-苯二胺(O-Pd)作为单体的电聚合,作为靶分子的单体作为单体。 RPG是一种新一代的口腔抗糖尿病药物,具有快速发作的作用和短的半衰期约为1?h。因此,需要开发具有良好敏感性和选择性的受控系统来消除其不利影响。在优化的条件下,所提出的传感器在具有类似结构和性质的化合物中检测RPG的良好选择性和具有RPG的化合物。分析的线性范围为0.005-1.0≤005-1.0Ωμm和检测极限1.8≤nm。此外,实验结果表明,所提出的传感器是高度选择性和敏感的,以检测真实样品中的RPG,例如血清,尿液和RPG片剂。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roushani Mahmoud&option=202" target="_blank" rel="nofollow">Roushani Mahmoud;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jalilian Zeynab&option=202" target="_blank" rel="nofollow">Jalilian Zeynab;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryIlam UniversityIlam Iran;</p> <p>Department of ChemistryPayame Noor University (PNU)Mashhad Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Repaglinide&option=203" rel="nofollow">Repaglinide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Molecularly imprinted polymer&option=203" rel="nofollow">Molecularly imprinted polymer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Electropolymerization&option=203" rel="nofollow">Electropolymerization;</a> </p> <div class="translation"> 机译:repaglinide;分子印迹聚合物;电聚合; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> 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