Longitudinal strain measured by two‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with myocardial bridging of the left anterior descending coronary artery

摘要

Abstract Objectives Myocardial bridging ( MB ) can cause myocardial ischemia, myocardial infarction, or even sudden cardiac death. We aimed to evaluate the left ventricular function in patients with MB of the left anterior descending coronary artery ( LAD ) using longitudinal strain ( LS ) measured by two‐dimensional speckle tracking echocardiography. Methods We enrolled 46 subjects with MB in the LAD diagnosed by coronary angiography. Patients were categorized into two groups according to the severity of tunneled artery stenosis: 50% as group I (23 patients) and ≥50% as group II (23 patients). Twenty‐five gender‐ and age‐matched subjects without MB confirmed by coronary angiography or with normal results on treadmill exercise test were included as controls. Two‐dimensional strain software was applied to measure the territories systolic average peak LS of the LAD coronary artery ( LAD ‐ TPLS ), right coronary artery ( RCA ‐ TPLS ), and left circumflex coronary artery ( LCX ‐ TPLS ) and to measure the global systolic peak LS of left ventricle ( LV ‐ GPLS ). Results The ratio of mitral peak early (E) and late (A) filling velocity (E/A) and the average mitral annular velocity (e′) were lower, and the mitral E/e′ ratio was higher in group II than in group I and controls ( P ??0.05). LV ‐ GPLS and LAD ‐ TPLS were significantly less negative in group II than in group I and controls ( LV ‐ GPLS : ?19.77?±?1.60% vs ?21.10?±?1.91% and ?21.76?±?1.23%; LAD ‐ TPLS : ?19.24?±?2.22% vs ?22.00?±?2.22% and ?22.74?±?1.82%, P? ? 0.001). The systolic compression severity of the tunneled artery was significantly correlated with LAD ‐ TPLS ( r ?=??0.56, P ??0.001), but less strongly correlated with LV ‐ GPLS ( r ?=??0.40, P ??0.05). The area under the curves of LAD ‐ TPLS was larger than that of LV ‐ GPLS ; a cutoff value for LAD ‐ TPLS of ?21.68% had 91.3% sensitivity and 73.9% specificity for detection of ≥50% of the tunneled artery stenosis. Conclusions In patients with ≥50% systolic narrowing of the tunneled artery, left ventricular systolic function and diastolic function were impaired, and the LAD ‐ TPLS is an excellent predictor of ≥50% systolic narrowing of the tunneled artery in patients with MB of the LAD .