Phenotype analyses of IL-10-producing Foxp3(-)CD4(+) T cells increased by subcutaneous immunotherapy in allergic airway inflammation

摘要

Introduction: The mechanisms of allergen immunotherapy are not fully elucidated. Here, we sought to develop a murine model to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) for allergic responses. As excessive antigen dosages may induce immune tolerance in sensitized mice, the effects of SCIT were assessed by varying the antigen dosage. The mechanisms of SCIT were analyzed by focusing on the induction of Foxp3(+) Treg cells and IL-10-producing Foxp3(-) CD4(+) T cells, as well as on the phenotype of the latter cells.