Synthesis of 2-Aryl-2-hydroxyethyl Dithiocarbamates via Regioselective Addition of Tetraalkylthiuram Disulfides to Styrenes under Transition-Metal-Free Conditions

摘要

This paper describes a method for the synthesis of 2-aryl-2-hydroxyethyl dithiocarbamates via difunctionalization of alkenes involving C-S and C-O bonds formation with tetraalkylthiuram disulfides as the functional reagents. The reaction proceeded well under transition-metal-free conditions and afforded up to 88% yield of the desired products. Numerous useful functional groups were tolerated under the reaction conditions. This methodology provides a direct approach to beta-hydroxy dithiocarbamates, featuring readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.