Synthesis of Aza-Heteroaromatic Dithiocarbamates via Cross- Coupling Reactions of Aza-Heteroaromatic Bromides with Tetraalkylthiuram Disulfides

摘要

The preparation of various aza-heteroaromatic dithiocarbamates from aza-heteroaromatic bromides and tetraalkylthiuram disulfides is reported. The transformation provides a convenient procedure, with good yields and functional group tolerance to various important nitrogen-containing heteroaromatic dithiocarbamates such as benzothiazole, quinoline, pyridine,and pyrazine motifs. This protocol allows the facile synthesis of some potential biologically active compounds.