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SYNTHESIS OF CHIRAL AMPHETAMINE DERIVATIVES BY STEREOSPECIFIC, REGIOSELECTIVE CUPRATE ADDITION REACTION WITH AZIRIDINE PHOSPHORAMIDATE COMPOUNDS
SYNTHESIS OF CHIRAL AMPHETAMINE DERIVATIVES BY STEREOSPECIFIC, REGIOSELECTIVE CUPRATE ADDITION REACTION WITH AZIRIDINE PHOSPHORAMIDATE COMPOUNDS
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机译:与氮丙啶胺磷酰胺化合物的立体选择性区域选择性加成反应合成手性安非他命衍生物
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摘要
The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
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