Synthesis and biological activity of a novel series of 6,7- dimethoxyquinazoline-2,4(1H,3H)-dione derivatives

摘要

The heterocyclic compounds are very important part of medicinal chemistry, among them it is worth to pay attention on derivatives of quinazo-line. They have a broad spectrum of pharmacological activities like anticancer (1-3), anti-HIV (3), antitubercular (4), anti-inflammatory (5), anticon-vulsant (6) and antihypertensive activity (7). The most recognized derivatives among quinazolines with antihypertensive activity are bunazosin or alfuzosin. Moreover, it was also reported that quinazolines have an interesting antimicrobial activity against different species of pathogenic G-positive bacteria, G-negative bacteria and fungi (8-12). Generally, it seems that quinazoline combined with different type of aryl, heteryl as well as alkyl substituents showed awide range of pharmacological applications.