Therapeutic Drug Monitoring of Naltrexone and 6-Naltrexol During Anti-craving Treatment in Alcohol Dependence: Reference Ranges

摘要

This article shows the use of therapeutic drug monitoring in alcohol dependent patients, who are treated with naltrexone. The plasma concentrations of naltrexone and 6-naltrexol showed high inter-individual variability. They were predictive for treatment response, as they correlated significantly with the reduction of alcohol craving.