Inverse Association of Serum Adiponectin Level with Body Mass Index in Peritoneal Dialysis Patients

摘要

BACKGROUND: Body mass index (BMI) is negatively correlated with adiponectin level in the general population. The aim of this study was to investigate the relationships of fasting serum adiponectin levels and the anthropometric components among peritoneal dialysis (PD) patients.METHODS: Fasting blood samples were obtained from 40 PD patients. Fasting adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. RESULTS: Univariate linear regression analysis results showed that body weight (r = -0.451; P = 0.003), waist circumference (r = -0.351; P = 0.026), BMI (r = -0.547; P < 0.001), body fat mass (r = -0.370; P = 0.019), white blood count (WBC; r = -0.584; P < 0.001), triglyceride (TG; r = -0.550; P < 0.001), fasting glucose (r = -0.349; P < 0.027), c-reactive protein (CRP; r = -0.340; P = 0.032), triceps skinfold (TSF; r = -0.427; P = 0.006), mid-arm circumference (MAC; r = -0.335; P = 0.034), and mid-arm fat area (MAFA; r = -0.446; P < 0.001) were negatively correlated with fasting serum adiponectin levels, whereas high-density lipoprotein cholesterol (HDL-C; r = 0.607; P < 0.001) was positively correlated with fasting serum adiponectin levels in PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that the HDL (R2 change = 0.368, P = 0.005) and BMI (R2 change = 0.159, P = 0.001) were independent predictors of fasting serum adiponectin levels. BMI cut-off points (underweight, normal, overweight, and obesity) were also inversely associated with serum adiponectin levels in PD patients (P = JO.001). CONCLUSIONS: Fasting adiponectin level was inversely associated with BMI among PD patients.