Synthesis of NIR Emitting Rare Earth Doped Fluorapatite Nanoparticles for Bioimaging Applications | Bentham Science

摘要

Aim: To synthesize biocompatible nanoparticles of FAp co-doped with Yb/Erand Nd/Yb for bioimaging applications.Methods: Yb/Er FAp and Nd/Yb FAp was synthesized using microwave assisted wet precipitationand hydrothermal method respectively. Trisodium citrate was used as an organicmodifier for the synthesis and then subjected to heat treatment for optical activation. Foroptical studies, Yb/Er FAp system was excited at 980 nm and Nd/Yb FAp at 800 nm.Results: In the case of Nd/Yb FAp the host matrix absorption and emission was observed,hence Nd/Yb was synthesized without citrate. On heat treatment of this for optical activationstudies, when the Yb3+ concentration was increased to 10 mol%, the YbPO4 secondaryphase was found to appear. Although, the Yb/Er FAp system resulted in large graingrowth, no such grain growth was observed in Nd/Yb FAp and the grains were within thenano size regime even after heat treatment.Conclusion: Both the systems showed successful energy transfer from sensitizer to activatorwith a quantum yield of 74% for Yb/Er FAp and energy transfer efficiency of 71% forNd/Yb FAp system. Both the samples were found to be cytocompatible and has the potentialfor using as probes for bioimaging applications.