Identification and evaluation of 2 circulating micro RNA RNA s for non‐small cell lung cancer diagnosis

摘要

Summary The circulating mi RNA s are dysregulated in non‐small cell lung cancer ( NSCLC ) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum mi RNA s for NSCLC diagnosis. We found that miR‐21 and let‐7a were significantly dysregulated in NSCLC patients ( P ??.001). When applied for NSCLC diagnosis, combined application of miR‐21 and let‐7a had a sensitivity of 0.790, specificity of 0.750, which is significantly higher than application alone of miR‐21(sensitivity 0.647; specificity 0.641), let‐7a (sensitivity 0.653; specificity 0.718) or computed tomography‐guided core‐needle biopsy ( CTCB ) (sensitivity 0.725; specificity 0.609) ( P ??.01). In conclusion, our study indicates that combined application of circulating miR‐21 and let‐7a has advantages over traditional CTCB technique.