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A comparative genomic hybridization approach to study gene copy number variations among chinese hamster cell lines

机译：一种对比较基因组杂交方法研究中国仓鼠细胞系中的基因拷贝数变异

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ABSTRACT <section xml:id="bit26311-sec-0001"> >Chinese Hamster Ovary (CHO) cells are aneuploid in nature. The genome of recombinant protein producing CHO cell lines continuously undergoes changes in its structure and organization. We analyzed nine cell lines, including parental cell lines, using a comparative genomic hybridization (CGH) array focused on gene‐containing regions. The comparison of CGH with copy‐number estimates from sequencing data showed good correlation. Hierarchical clustering of the gene copy number variation data from CGH data revealed the lineage relationships between the cell lines. On analyzing the clones of a clonal population, some regions with altered genomic copy number status were identified indicating genomic changes during passaging. A CGH array is thus an effective tool in quantifying genomic alterations in industrial cell lines and can provide insights into the changes in the genomic structure during cell line derivation and long term culture. Biotechnol. Bioeng. 2017;114: 1903–1908. ? 2017 Wiley Periodicals, Inc. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> <section XML：ID =“Bit26311-SEC-0001”> >中文仓鼠卵巢（CHO）细胞是一种自然的一种动力倍性。产生Cho细胞系的重组蛋白的基因组连续经历其结构和组织的变化。我们分析了九种细胞系，包括父母细胞系，使用聚焦在含基因的区域上的对比基因组杂交（CGH）阵列。 CGH与测序数据的拷贝数估计的比较显示出良好的相关性。来自CGH数据的基因拷贝数变型数据的分层聚类揭示了细胞系之间的谱系关系。在分析克隆人群的克隆上，鉴定了一些具有改变的基因组拷贝数状态的区域，表明在传代期间的基因组变化。因此，CGH阵列是定量产业细胞系中基因组改变的有效工具，并且可以在细胞系衍生期间和长期培养过程中对基因组结构的变化提供见解。 Biotechnol。生物。 2017; 114：1903-1908。还2017 Wiley期刊，INC。</ p> </段> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15017/'>《Biotechnology and Bioengineering》</a> <b style="margin: 0 2px;">|</b><span>2017年第8期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vishwanathan Nandita&option=202" target="_blank" rel="nofollow">Vishwanathan Nandita;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bandyopadhyay Arpan&option=202" target="_blank" rel="nofollow">Bandyopadhyay Arpan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fu Hsu‐Yuan&option=202" target="_blank" rel="nofollow">Fu Hsu‐Yuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Johnson Kathryn C.&option=202" target="_blank" rel="nofollow">Johnson Kathryn C.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Springer Nathan M.&option=202" target="_blank" rel="nofollow">Springer Nathan M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hu Wei‐Shou&option=202" target="_blank" rel="nofollow">Hu Wei‐Shou;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Chemical Engineering and Materials ScienceUniversity of Minnesota421 Washington Avenue SE Minneapolis Minnesota 55455‐0132;</p> <p>Department of Chemical Engineering and Materials ScienceUniversity of Minnesota421 Washington Avenue SE Minneapolis Minnesota 55455‐0132;</p> <p>Department of Chemical Engineering and Materials ScienceUniversity of Minnesota421 Washington Avenue SE Minneapolis Minnesota 55455‐0132;</p> <p>Department of Chemical Engineering and Materials ScienceUniversity of Minnesota421 Washington Avenue SE Minneapolis Minnesota 55455‐0132;</p> <p>Microbial and Plant Genomics Institute and Department of Plant BiologyUniversity of MinnesotaSt. Paul Minnesota;</p> <p>Department of Chemical Engineering and Materials ScienceUniversity of Minnesota421 Washington Avenue SE Minneapolis Minnesota 55455‐0132;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chinese hamster ovary cell lines&option=203" rel="nofollow">Chinese hamster ovary cell lines;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=copy number variants&option=203" rel="nofollow">copy number variants;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=comparative genomic hybridization&option=203" rel="nofollow">comparative genomic hybridization;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sequencing&option=203" rel="nofollow">sequencing;</a> </p> <div class="translation"> 机译：中国仓鼠卵巢细胞系;拷贝数变体;比较基因组杂交;测序; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li 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