Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex

Huang Min; Luo Limin; Zhang Yu; Wang Wenying; Dong Jing; Du Wenjie; Jiang Wei; Xu Tao

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Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex

机译：代谢谷氨酸受体5信号传导诱导的NMDA受体亚基在小鼠皮层中吗啡诱导的抗闭合性耐受性期间发生变化

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摘要

Background and purpose: The aim of this study was to investigate the interactions between mGluR5 and NMDAR during the development of tolerance to the analgesic effect of chronic morphine following disruption of the link between mGluR5 and NMDAR.

机译：背景和目的：本研究的目的是研究MGLUR5和NMDAR在发育慢性吗啡破坏MGLUR5和NMDAR之间的联系后镇痛作用的镇痛作用的耐受性之间的相互作用。

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来源
《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2019年第2019期|共10页
作者
Huang Min; Luo Limin; Zhang Yu; Wang Wenying; Dong Jing; Du Wenjie; Jiang Wei; Xu Tao;
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作者单位

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

Shanghai Jiao Tong Univ Affiliated Shanghai Peoples Hosp 6 Dept Anesthesiol 600 Yi Shan Rd;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Morphine; Tolerance; mGluR5; NMDA receptor; Shank3; Hyperalgesia;

机译：吗啡;耐受;mglur5;nmda受体;shank3;vervargegaina;

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专利

1. Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex [J] . Huang Min, Luo Limin, Zhang Yu, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第期

机译：代谢谷氨酸受体5信号传导诱导的NMDA受体亚基在小鼠皮层中吗啡诱导的抗闭合性耐受性期间发生变化
2. Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt|[sol]|GSK-3|[beta]| Pathway in Adult Rat Prefrontal Cortex [J] . Dong Xi, Yan-Chun Li, Melissa A Snyder, Neuropsychopharmacology . 2011,第6期

机译：II组代谢型谷氨酸受体激动剂通过Akt | [sol] | GSK-3 |β|减轻MK801诱导的NMDA受体功能障碍。成年大鼠前额叶皮层的通路
3. Alterations of NMDA and AMPA receptors and their signaling apparatus in the hippocampus of mouse offspring induced by developmental arsenite exposure [J] . Fenghong Zhao, Zijiang Wang, Yingjun Liao, The Journal of toxicological sciences . 2019,第11期

机译：发育亚砷酸盐引起的小鼠后代海马中NMDA和AMPA受体及其信号传导装置的变化
4. Age-dependent expression of NMDA receptor subunit NR2B protein and the effects of early auditory deprivation and experience in rat auditory cortex [C] . XU Jing-Hong, WU Xiu-Mei, ZHANG Ling, 2006年第二届上海国际生理生物物理大学 . 2006

机译：NMDA受体亚基NR2B蛋白的年龄依赖性表达以及大鼠听皮层早期听觉剥夺和经验的影响
5. The functional roles of metabotropic glutamate receptors in prefrontal cortex and the implications in Alzheimer's disease. [D] . Tyszkiewicz, Joanna P. 2006

机译：代谢型谷氨酸受体在前额叶皮层中的功能作用及其在阿尔茨海默氏病中的意义。
6. Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex [O] . Shamseddin Ahmadi, Fatemeh Rafieenia, Jalal Rostamzadeh 2016

机译：吗啡诱导的镇痛耐受性对大鼠纹状体和前额叶皮层NMDA受体亚基1基因表达的影响
7. Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex [O] . S. Ahmadi, F. Rafieenia, J. Rostamzadeh 2016

机译：对大鼠纹状体和前额外皮层中NMDA受体亚基1基因表达的吗啡诱导的镇痛耐受影响

Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex

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