Ever-Pregnant Female Blood Donors and Mortality Risk in Male Recipients

摘要

To the Editor A retrospective cohort study found an association between transfusion from an ever-pregnant female donor and increased mortality among male recipients—predominantly younger males—but not female recipients.~(1) However, the actual indication for the transfusion is a relevant confounder that remains uncorrected for in the study. The 2010 Dutch Profiles of Transfusion Recipients (PROTON) study showed that indications for blood transfusion in the Netherlands, the country of provenance of the study, differed markedly between men and women.~(2) The principal indication for blood transfusion in younger male recipients in the Netherlands was injury, whereas for younger women it was pregnancy and childbirth. The international Clinical Randomization of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) randomized clinical trial looked specifically at trauma patients and found that 84% of the 20?206-person cohort were men and 77% were younger than 44 years.~(3)