Antimicrobial and contraceptive composition that reduces the risk of transmission of, or infection by, sexually transmitted disease through sexual activity involving a female's vagina and a male's penis and method of reducing the risk of transmission and infection by a sexually transmitted disease. through sexual activity involving a female's vagina and a male's penis

摘要

"ANTIMICROBIAN AND CONTRACEPTIVE COMPOSITION THAT REDUCES THE RISK OF TRANSMITTING OR INFECTION BY SEXUALLY TRANSMITTED DISEASE THROUGH A FEMALE AND A PENIS OF A MALE AND A MECO INFECTION REDUCUS TRANSMITTED THROUGH SEXUAL ACTIVITY INVOLVING A FEMALE'S VAGINA AND A MALE PENIS ". Antimicrobial and contraceptive compositions and methods that prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity and that also prevent and / or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix forming agent, (2) a bioadhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; the composition being suitable for application to the vagina; wherein the composition forms a semi-solid matrix when in contact with ejaculate (thereby trapping sperm and ejaculate microbes); the composition causing hardening of cervical mucus (thereby reducing the likelihood of sperm entry); the composition forms a bioadhesive layer on vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with vaginal surfaces); wherein the composition maintains an acid vaginal pH less than about 5 in the presence of male ejaculated semen; and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidines, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde copolymers, mandelic acid copolymers, modified with H 2 2 SO 4, iodine povidone, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, and cyclopiroxolamine, and the like).