Tularemia vaccine: Safety, reactogenicity, 'Take' skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial

摘要

Background: Tularemia is caused by Francisella tularensis, a gram-negative bacterium that has been weaponized as an,aerosol. For protection of personnel conducting biodefense research, the United States Army required clinical evaluation of a new lot of tularemia live vaccine strain manufactured in accordance with Current Good Manufacturing Practices.