Tularemia Vaccine: Safety Reactogenicity Take Skin Reactions and Antibody Responses following Vaccination with a New Lot of the Francisella tularensis Live Vaccine Strain - A Phase 2 Randomized Clinical Trial

摘要

BackgroundTularemia is caused by Franciscella tularensis, a gram-negative bacterium that has been weaponized as an aerosol. For protection of personnel conducting biodefense research, the United States Army required clinical evaluation of a new lot of tularemia live vaccine strain manufactured in accordance with Current Good Manufacturing Practices.