Discovery of A Highly Potent and Selective Capsid Assembly Inhibitor (WX-066) For the Treatment of Chronic HBV Infection

He Haiying; Li Xiaolin; Zhou Kai; Wang Xiaofei; Zhou Yuedong; Zhou Qiong; He Shibo; Jin Huangtao; Gu Zhengxian; Shen Liang; Hou Lijuan; Li Jian; Chen Shuhui; Cheng Zhe; Sun Chunyan; Zhang Long; Zhao Shuyong

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Discovery of A Highly Potent and Selective Capsid Assembly Inhibitor (WX-066) For the Treatment of Chronic HBV Infection

机译：发现高效和选择性衣壳组装抑制剂（WX-066），用于治疗慢性HBV感染

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2017年第1期|共1页
作者
He Haiying; Li Xiaolin; Zhou Kai; Wang Xiaofei; Zhou Yuedong; Zhou Qiong; He Shibo; Jin Huangtao; Gu Zhengxian; Shen Liang; Hou Lijuan; Li Jian; Chen Shuhui; Cheng Zhe; Sun Chunyan; Zhang Long; Zhao Shuyong;
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WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

WuXi AppTec Shanghai Co Ltd Shanghai Peoples R China;

Qilu Pharmaceut Co Ltd Shandong Prov Key Lab Small Mol Targeted Drugs Jinan Shandong Peoples R;

Qilu Pharmaceut Co Ltd Shandong Prov Key Lab Small Mol Targeted Drugs Jinan Shandong Peoples R;

Qilu Pharmaceut Co Ltd Shandong Prov Key Lab Small Mol Targeted Drugs Jinan Shandong Peoples R;

Qilu Pharmaceut Co Ltd Shandong Prov Key Lab Small Mol Targeted Drugs Jinan Shandong Peoples R;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Discovery of A Highly Potent and Selective Capsid Assembly Inhibitor (WX-066) For the Treatment of Chronic HBV Infection [J] . He Haiying, Li Xiaolin, Zhou Kai, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：发现高效和选择性衣壳组装抑制剂（WX-066），用于治疗慢性HBV感染
2. Discovery of (3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo(2,3-b)pyridin-1-yl)acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. [J] . Van-Zandt MC, Doan B, Sawicki DR, Bioorganic and Medicinal Chemistry Letters . 2009,第7期

机译：发现（3-（4,5,7-三氟噻唑-2-基甲基） - 吡咯（2,3-B）吡啶-1-基）乙酸作为醛糖还原酶的高效和选择性抑制剂，用于治疗慢性糖尿病并发症。
3. Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid(Lidorestat)and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications [J] . Michael C.Van Zandt, Michael L.Jones, David E.Gunn, Journal of Medicinal Chemistry . 2005,第9期

机译：发现3-[（4,5,7-三氟苯并噻唑-2-基）甲基]吲哚-N-乙酸（Lidorestat）及其同类物作为醛糖还原酶的强效和选择性抑制剂，可治疗慢性糖尿病并发症。
4. PROTEIN EPITOPE MIMETICS: AN INNOVATIVE APPROACH TO THE DISCOVERY OF SELECTIVE AND HIGHLY POTENT SERINE PROTEASE INHIBITORS [C] . Odile Sellier, Francoise Jung, Steve J. DeMarco the European Peptide Symposium . 2007

机译：蛋白表位模拟方法：一种创新的选择性和高效丝氨酸蛋白酶抑制剂的方法
5. Discovery and characterization of potent and selective inhibitors against the PEA-hydrolyzing enzyme, N-acylethanolamine-hydrolyzing acid amidase. [D] . Solorzano Say, Carlos Efrain. 2010

机译：发现和表征针对PEA水解酶，N-酰基乙醇胺水解酸酰胺酶的有效和选择性抑制剂。
6. Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) [O] . Jiaxin Wu, Aoli Wang, Xixiang Li, 2019

机译：发现和表征一种新型的强效和选择性II型天然和耐药V299L突变型BCR-ABL抑制剂（CHMFL-ABL-039）用于治疗慢性粒细胞白血病（CML）
7. Discovery of 3-(4, 5, 7-Trifluorobenzothiazol-2-yl)methylindole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications [O] . -1

机译：发现3 - （4,5,7-三氟噻唑-2-基）甲基吲哚-N-乙酸（LIDORESTAT）和作为醛糖还原酶的高效和选择性抑制剂，用于治疗慢性糖尿病并发症

Discovery of A Highly Potent and Selective Capsid Assembly Inhibitor (WX-066) For the Treatment of Chronic HBV Infection

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